There is growing awareness of the need to move beyond the ‘one-size-fits-all’ approach in nutritional advice. However, for personalised nutrition to become a reality, large-scale, high precision data integrating multiple dietary, lifestyle, physiological, genetic and metagenomic data is required. This talk will explore 1) why we need personalised approaches to nutrition advice, 2) the current status of personalised nutrition and large-scale data collection in remote clinical trials and 3) new developments with a focus on the ZOE PREDICT programme of research.